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KMID : 1161520080120010035
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Animal Cells and Systems
2008 Volume.12 No. 1 p.35 ~ p.39
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Identification of hexapeptides that render C2 myoblasts the resistant to menadione-induced cell death
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Hwang Sung-Ho
Kim Min-Jeong
Lim Jeong-A
Woo Joo-Hong
Kim Hye-Sun
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Abstract
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Menadione induced cell death in cultured C2 myoblasts. By screening synthetic peptide libraries composed of random sequence of hexapeptides, we identified the hexa?peptides pool of (Ala/Ile)?(Ile/Met)?Val?Ile?Asp?(Met/ Ser)?NH2 that protected the myoblasts against menadione?induced cell death. Pre?incubation with the hexapeptide pool reduced the number of cells detached from culture dish substrate and increased the ratio of relative viability against menadione. In addition, the peptides strongly increased the expression of Bcl?2, an anti?apoptotic protein. These results suggest that the hexapeptides might enhance the resistance to cell death against menadione by increasing the expression of Bcl?2.
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KEYWORD
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C2 myoblasts, menadione, oxidative stress, cell death, hexapeptides, Bcl-2
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